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자연과학대학 - 생명과학과

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    Lab 분자세포당생물학연구실

관심분야 

Research interests are the field of glycomics and glycobiology, expecially on sphingolipid, ceramide and sialic acid-containing sphingolipids, ganglioside. Academic findings: Hepatic B Viral hepatocarcinoma and PTEN (Cancer Res 2003), asialo-1 acid glycoprotein in liver cirrhosis and carcinoma (Hepatol Res, 2003), GlcNAc:βMan1,4GlcNAcT-III in hepatitis (Glycoconj J, 2003), MMP-9/2 and α-fetoproteins in HBV hepatitis (J. Gastroent Hepatol 2004), HBV metastatic (FASEB J. 2004), Hepatic GnT-V and GnT-III-ApoB100 (JBC. 2004), Disialo GD3 in VSMC (JBC. 2004), therapeutic hepatocarcinoma cells (FASEB J. 2004), TG-2  in leukemia (FEBS Lett. 2004), N-GlcNAcT-III in HBV (J Gastroent Hepatol, 2004), Monosialyl GM3 in leukemic differentiation (Glycobiology 2005), MMP-9 in IVF (British J Obstetrics and Gynecol. 2005), disialo GD3 Fas-T cells (Glycobiology 2006), GM3 in PTEN (Glycobiology 2006), ROS in sialic GD3-cell  (FASEB J 2006), AP-2a in GM3-PTEN (Glycobiology 2008), sialidase in leukemia (BBA 2008), GM3-VEGFR-2 interaction (Glycobiology 2009), GD3 in breast cancer (Biological Chemistry 2009), pig CMAH and N-glycolylneuraminic acid (Biochem J 2010), pST6GalNAc IV for Neu5Aca2-3Galb1-3GalNAc (Glycoconj J 2011), GM3 in TGF-β1-induced EMT (Biochem J. 2013), VEGFR-2 in neovascularization (J Mol Medicine 2013), monosialyl GM3 (Plos One 2014) and TGF-receptor  (Int. J. of Biochem. Cell Biol. 2014), Sialyl Le A/X of HBx (Mol Cancer 2014, J Cell Biochem 2015). Housekeeping promoter 5'pcmah-2 of  CMP-NeuGc gene (Glycoconj 2016),  GD1b Apoptosis of MCF-7 (IJMS 2016), Human ST8Sia VI (α2,8-Sialyltransferase) Gene (IJMS 2016), GD2-ICAMI (IJMS 2017), Sialyllactose  VEGFR-2 activation, GD3/a1AR/TG2, AApoB100-GM3, GM3-macrophage  (JCB, 2017, 2018), Sirt1-FcεRI- mast cell AMPK (Sci Rep, 2017), ASC/LPS (PloS One 2017), 4-o-cASC (JCB, JSMB 2018), SARS-CoV-2-sialylation. Lectin-Glycan (IJMS, 2020),CMP-NeuGc (Sci Rep 2019), AC (FP), 3-SL-sIGLEC (Glycoconj J 2020), Avc(FP, 2021, IJMS 2021)

학력

  • (PhD) 1990 동경대학 대학원 석사 및 박사

약력/경력

  • 2006-현재 성균관대학교 생명과학과 교수, 삼성융합의과학원 교수, 학과장
  • 2015 July ~ 2016 Jan 미국 오하이오 주립대학 Functional Genomics 객원교수
  • 2010 ~ 2011 일본국 토카이 대학교 당쇄과학연구소 객원교수
  • 2020-현재 일본국 후쿠오카 쥰신 대학교 비상근 교수
  • 1996 ~ 2006 동국대학교 한의과대학 생화학교실 조교수, 부교수, 정교수, 주임교수, 한의학과장
  • 1990 ~ 1996 한국과학기술연구원 유전공학센터, 현재 한국생명공학연구원 분자생물학실 선임연구원 및 게놈연구담당 실장
  • 1987 ~ 1989 일본국 동경의약대학 생물공학과 비상근강사
  • 2010 ~ 현재, Frontiers in Pharmacology 및 eCAM 부편집위원, Current Pharm. Biotechnol 공동편집위원장
  • 2010 ~현재, The Peer Journal, Int J Molec Sci 편집위원

학술지 논문

  • (2024)  Dawn era for revisited cancer therapy by innate immune system and immune checkpoint inhibitors.  Biochimica et Biophysica Acta - Molecular Basis of Disease.  1870,  3
  • (2024)  A novel Mycobacterium Tuberculosis antigen, MTB48 enhances inflammatory response in LPS-induced RAW264.7 macrophage immune cells.  MOLECULAR IMMUNOLOGY.  166,  2
  • (2023)  The Derivatives of Cromolyn Ameliorate the Abnormal Misfolding of Amyloid Proteins and Neuroinflammation in the Neural Cells.  CURRENT MEDICINAL CHEMISTRY.  30,  39
  • (2023)  T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.  750,  12
  • (2023)  Regulatory mechanism for the human glioblastoma cell-specific expression of the human GD1c/GT1a/GQ1b synthase (hST8Sia V) gene.  GLYCOCONJUGATE JOURNAL.  23,  12
  • (2023)  Upregulation of human GD3 synthase (hST8Sia I) gene expression during serum starvation-induced osteoblastic differentiation of MG-63 cells.  PLOS ONE.  18,  11
  • (2023)  Editorial: The innate and adaptive immune system in human urinary system..  FRONTIERS IN IMMUNOLOGY.  14,  1294869
  • (2023)  Editorial: Mechanisms during bacterial infection: cellular recognition, signalling, and regulation.  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.  2023,  09
  • (2023)  Editorial Insights in ethnopharmacology 2022.  FRONTIERS IN PHARMACOLOGY.  14,  2023
  • (2023)  Up-regulation of inflammatory reactions by MPT32, a secreted protein of Mycobacterium tuberculosis in RAW264.7 macrophages.  JOURNAL OF CELLULAR BIOCHEMISTRY.  124,  9
  • (2023)  5-Methylthiopentyl Isothiocyanate, a Sulforaphane Analogue, Inhibits Pro-inflammatory Cytokines by Regulating LPS/ATP-mediated NLRP3 Inflammasome Activation.  CURRENT PHARMACEUTICAL BIOTECHNOLOGY.  24,  16
  • (2023)  Naturally-Occurring Tyrosinase Inhibitors Classified by Enzyme Kinetics and Copper Chelation.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  24,  9
  • (2022)  Physiological Properties, Functions, and Trends in the Matrix Metalloproteinase Inhibitors in Inflammation-Mediated Human Diseases.  CURRENT MEDICINAL CHEMISTRY.  2022,  10
  • (2022)  Synthesis of a- and α-series gangliosides during differentiation of leukemic HL-60 and THP-1 cells.  Clinical and Translational Discovery.  2,  3
  • (2022)  Curcumin-mediated transcriptional regulation of human N-acetylgalactosamine-a2,6-sialyltransferase which synthesizes sialyl-Tn antigen in HCT116 human colon cancer cells.  FRONTIERS IN MOLECULAR BIOSCIENCES.  9,  -
  • (2022)  Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  23,  17
  • (2022)  Glycan-Adhering Lectins and Experimental Evaluation of a Lectin FimH Inhibitor in Enterohemorrhagic Escherichia coli (EHEC) O157:H7 Strain EDL933.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  23,  17
  • (2022)  Molecular Research of Glycolysis.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  23,  9
  • (2022)  Mycobacterium tuberculosis glycolipoprotein LprG inhibits inflammation through NF-kappa B signaling of ERK1/2 and JNK in LPS-induced murine macrophage cells.  JOURNAL OF CELLULAR BIOCHEMISTRY.  123,  4
  • (2022)  Systemic Lectin-Glycan Interaction of Pathogenic Enteric Bacteria in the Gastrointestinal Tract.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  23,  3

단행본

  • (2024)  Glycoimmunology in Xenotransplantation.  Nature Springer.  단독
  • (2022)  Glycobiology of Innate Immunology.  Nature Springer Publishing.  단독
  • (2021)  Glycosphingolipids signaling.  Nature Springer.  단독
  • (2020)  GM3 Signaling.  Nature Springer.  단독
  • (2020)  Ganglioside Biochemistry.  Nature Springer.  단독
  • (2015)  Caffeic Acid Biological Properties, Structure and Health Effcts 단행본의 Chapter 5, Molecular, Pharmacological and Chemical Biology of Caffeic Acid and Derivatives 저작.  Nova Science Publishers.  주저자

특허/프로그램

  • 해파리 Jellyfish Hexane Extract의 인간 만성골수성백혈병, 인간 간암 및 인간 대장암 예방 및 치료제.  10-2016-0045914.  20170808.  대한민국
  • 항암제cisplatin과 ganglioside GM3 및 그 당쇄체인 a2-3sialyllactos 병용투여를 통한 종양암 효과적 치료법 개발.  10-2014-0092477.  20170607.  대한민국
  • 불가사리 추출물을 포함하는 항 비만용 조성물.  10-2013-0169197.  20150612.  대한민국
  • 돼지 ＣＭＡＨ 유전자 발현 프로모터 및 이를 억제하여 제조된 이종장기 이식용 돼지세포주.  10-2012-0084164 .  20141111.  대한민국
  • 불가사리 추출물을 포함하는 항 비만용 조성물.  10-2011-0020114 .  20141021.  대한민국
  • 항동맥경화활성과 혈관질환예방 및 억제활성을 갖는 저온진공으로 추출한 장어 뼈-가공부산물의 추출물및 그 제조방밥.  2014-0061007.  20140915.  대한민국
  • 안질환의 예방 또는 치료용 조성물.  2011 533097.  20140912.  일본
  • 항산화활성을 갖는 저온진공으로 추출한 장어 뼈-가공부산물의 추출물 및 그의 제조방법.  2012-0062723.  20140526.  대한민국
  • 장어 뼈-가공부산물 분말의 콜레스테롤 개선을 위한 건강식품 조성물.  2011-0046217.  20131202.  대한민국
  • 장어추출물을 유효성분으로 함유하는 염증성 질환예방 또는 치료용 조성물.  2011-0044554.  20131001.  대한민국
  • Composition for prevention or treatment of eye diseases.  PCT/kr2009/005983.  20130903.  미국
  • HBV성 간암진단.  10-2008-0098522.  20120803.  대한민국
  • 안질환의 예방 또는 치료용 조성물(Compositions for Preventing or Treating of Eye Diseases).  10-2008-0102660.  20120208.  대한민국
  • 신규한 이종항원 및 그의 용도.  10-2011-0006304.  20120130.  대한민국
  • 불가시리 추출물을 유효성분으로 포함하는 MMP-9 또는 MMP-2의 과다발현에 기인한 질환의 예방 및 치료용 조성물.  10-2008-0098523.  20110802.  대한민국
  • 백혈병 예방 또는 치료용 약제학적 조성물.  10-2008-0026704.  20100701.  대한민국
  • 독활 추출물 을 주요성분으로 함유하는 동맥경화 예방 및 치료용 조성물.  10-0801511.  20080130.  대한민국
  • 단삼 추출물 및 분획물을 함유하는 동맥경화증의 예방 또는 치료용 조성물.  10-0767238.  20071009.  대한민국
  • 종양발생및 전이에 관여하는 당단백질의 당쇄변화를 측정하는 방법 (An analyzing method for measuring the changes of glycosylation in various glycoprotein).  제10-0767018호.  20071008.  대한민국
  • Method of Diagnosing the changes of pregnancy and the diagnostic kit for the same..  United States Patent US 7,060,502 B2.  20060613.  미국

수상/공훈

  • 과학기술 포장 2004

학술회의논문

  • (2023)  ER-Golgi network glycosylation during cellular differentiation and anti-cancer and cardiovascular mechanism(s) of natural products.  38th Inte5rnational Annual Meeting in Pharmaceutical Sciences (IAMPS38).  태국
  • (2019)  e-Membranome: a database for genome-wide analysis of Escherichia coli outer-membrane proteins..  2019한국미생물학회연합 정기학술대호.  대한민국
  • (2019)  Genome-Wide Construction of Lectin-Glycan Interaction (LGI) Network in the Early Stage of Enterotoxigenic E. coli (ETEC) Infections.  KMB2019 46th Annual meeting and International Symp..  대한민국
  • (2019)  Development of Membranome Database by Genome-Wide Analysis to construct Lectin-Glycan Interaction (LGI) Network in Enterohemorrhagic E. coli (EHEC) and Enterotoxigenic E. coli (ETEC)..  한국미생물학회 2019추계학술대회 제137차.  대한민국
  • (2019)  A genome-wide construction of lectin-glycan interaction (LGI) network in the early stage of enterohemorrhagic E. coli (EHEC) infections..  EMBO/EMBL Symposium유럽분자생물학기구 심포지움.  독일
  • (2017)  ASCOFURANONE INHIBITS LIPOPOLYSACCHARIDE-INDUCED INFLAMMATORY RESPONSE VIA NF-KAPPAB AND AP-1, P-ERK, TNF-α, IL-6 AND IL-1β IN RAW 264.7 MACROPHAGES.  3rd International Conference on Natural Products Utilization:From Plants to Pharmacy Shelf.  불가리아
  • (2017)  ESCULENTOSIDE H INHIBITS COLON CANCER MIGRATION AND INVASION BY SUPPRESSION OF MMP-9 GENE EXPRESSION VIA JNK1/2 AND NF-κB SIGNALING PATHWAY.  3rd International Conference on Natural Products Utilization:From Plants to Pharmacy Shelf.  불가리아
  • (2017)  REVISITING OLDENLANDIA DIFFUSA TO ANTI-METASTATIC AND APOPTOTIC POTENTIAL IN BREAST CANCER BY ANTI-MMP-9 AND ICAM-1VIA p38 AND ERK1/2 MAPK.  3rd International Conference on Natural Products Utilization:From Plants to Pharmacy Shelf.  불가리아
  • (2017)  ESCULENTOSIDE B INHIBITS LPS-STIMULATED INFLAMMATORY RESPONSE THROUGH NF-KB, ERK1/2, P38, IL-6, IL-1Β IN RAW264.7 MACROPHAGE CELLS”.  3rd International Conference on Natural Products Utilization.  불가리아
  • (2016)  Carbohydrate xenoantigens in pig to human xenotransplantation.  Journal of Glycobiology.  미국
  • (2016)  Disialyl ST8Sia I (GD3 synthase) accumulates GD2 ganglioside and suppress ICAM-1-mediated invasiveness in human breast cancer MDA-MB231 cells.  Journal of Glycobiology.  미국
  • (2016)  Glyco Immunology, Glycans in Drug Design 분야.  Journal of Glycobiology.  미국
  • (2016)  Identification of housekeeping basal promoter 5’pcmah-2 of pig CMP-N-acetylneuraminic acid hydroxylase gene.  Journal of Glycobiology.  미국
  • (2016)  Intestine specific regulation of pig CMP-N-acetylneuraminic acid hydroxylase gene (pcmah) is specifically controlled by Sp1 binding sites on its promoter: 5’pcmah-1 containing exon 1a and common ORF region (exon 2 to exon 14) is intestine specific..  Journal of Glycobiology.  미국
  • (2016)  해파리추출물의 항암작용 기전연구.  종양및 면역질환의 유전적치료및 연구개발 심포지움.  대한민국
  • (2016)  4-O-methyl-ascochlorin-reduced C-Myc expression promotes apoptosis of leukemia cells by an AMPK.mTOR-dependent pathway.  16th International Conference of Biochemistry and Molecular Biology.  캐나다
  • (2016)  Suppression of C-Myc enhances p21WAF1/CIP1-mediated G1 cell cycle arrest through the modulation of ERK phosphorylation.  16th International Conference ofBiochemistry and Molecular Biology.  캐나다
  • (2015)  Antitumor activity of eel skin mucus, containing lactose-recognizing molecules, on human leukimic cancer cells.  International Conference of the Korean Society for Molecular and Cellular Biology.  대한민국
  • (2015)  Autophagy by dendropanoxide can either rpress or promote cell death in colon cancer cells.  International Conference of the Korean Society for Molecular and Cellular Biology.  대한민국
  • (2014)  Natural compound dendropanoxide-induced autophagy can either suppress or promote cell death in colon cancer cell lines.  Journal of Biotechnology and Biomaterials.  스페인

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